As an organic chemist, I would put my bets on electrostatic interactions ( cell walls, virus spike active sites) as to why CPC is so effective in deactivating this virus almost instantly. I don’t see any role for NO here, though by itself NO is powerful. With its similar structure, Nicotine could be as effective, for the same reasons. It is very much amenable for a synthetic conversion to a CPC analogue, in which case it is my guess that it can be devastatingly powerful for the virus. This conversion might possibly eliminate the concerns about nicotine. Any takers for this simple exploration ? Nicotine is used for weaning from smoking and as such all that is wrong about tobacco should not be ascribed to it. Tobacco has more than 3000 identified chemical constituents, including other alkaloids. Also, we are looking at only short/medium term therapy with these molecules, ideally in combination with others.
I personally saw a smoker I know get very sick with the delta variant, so I'm not convinced nicotine alone is the preventative answer to our anti-viral questions. Plus, I experimented with one of those nicotine patches (7mg) for my long-covid and it made me very sick. Maybe the lower dose nicotine gum would work, but 7mg is what has been used and said to work for some people. I've also seen what chewing tobacco does to some people the first time they chew it, not good. Nicotine poisoning is a real thing.
I think it's interesting that while I am an asthmatic, I have never had covid pneumonia.
Breathing in through the nose delivers NO directly into the lungs, where it helps fight coronavirus infection by blocking the replication of the coronavirus in the lungs.
I have read somewhere that Nicotine is not the main reason for the ills of Tobacco. It is a recreational drug. However, people could be sensitive to anything and in your example, nicotine was perhaps on the wrong side. I referred to it in my last line and I have specifically highlighted often in other places - single drugs are ok if the condition is prophylactic, like with Ivermectin in Covid, but in a fresh infection, therapy/treatment with repurposed drugs has to be a cocktail of drugs, including with Ivermectin. And it could be true of Nicotine also, in your example, used as the lone drug. For delta, it should have been part of a combination of Azithromycin, Montelukast, Levocetrizine etc, the most successful bunch that drove delta out of the park in India in the second half of 2021. The premise is simple. All these are part anti virals off label, this could include Nicotine also in my understanding. In the viral phase in the initial days, as the viral load rapidly grows, just a single drug may not be adequate to contain the build up, in most people. Only a combination of such molecules would pack enough anti viral fire power for the job. A simple clinical judgment miserably missed or ignored by the clinicians in the USA. This is true with Omicron also. Its mild presentations are deceptive. It is clear from the US experience that it too is capable off long Covid damages. So early combination drugs are needed to not let viral load build up beyond tipping levels. In my opinion, this could be true of the highly hailed Paxlovid also. As single drug, it did not have enough fire power and that is how its efficacy was about 30-40%. It needed the back up of one or two classical URT medicines. On Nicotine, the chemical magic could be to convert it in a simple step as a CPC analog. In my reckoning, such a molecule would have two anti viral points - the Cetyl quaternary Pyridine ring and and the existent N-methyl pyrrolidone point, which is a powerful tertiary amine location in the structure. It is still a new molecule, despite its similarity to two known drug molecules, and needs to go through its safety profile drill, after a quick in vitro evaluation.
Moro, it's always a joy to hear from you. While I do hold a minor in chemistry, I have to confess that organic chemistry was not my favorite year of learning, and the most profound thing I remember my O chem prof saying is that eating margarine is probably a bad idea. Biochemistry is something I enjoyed more than O chem, but clinical chemistry rocked my world because of the way the science of chemistry became the vehicle for diagnostic medicine to be used to heal people. Practical medicine needs science, but as you know applying that science is not as easy as the scientific studies often make things seem. Medicine also needs to catch up with science, I've heard its way behind in applying current scientific knowledge. Much wisdom is needed in order for each sick person to become an active participant in their treatment decisions. God bless you!
Thanks for your kind words. Appreciate. I have never worked in drug synthesis or developments and in the last few years, got attracted to reading about organic structures of drugs ( in my long retirement since). During those three plus years of Covid and following many reports on repurposed drugs, I looked at the structures of over 700 known drugs and formed a thought about some commonality in them ( not achieved by design certainly, but falling in place), about many of them being anti viral ( to viruses like the present one) and since have been propounding the view that 2000-3000 drug molecules we know today and use, some decades old, have multi indication potentials that must become the medicine pursuit for this century. In the process, helping half the population of the world who are now without access for cheap, effective, safe, readily available drugs - from cancer down to any everyday illness. I take part actively in conversations in quite a few good podcasts, including Dr. McMillan’s. I could be the only one in the hundreds and hundreds of active followers, talking from pure chemistry perspectives of drugs and treatments, even though I am not a medico myself. In recent times, I got Dr. Shankara Chetty interested in the possibility that ionic structured drugs could be powerful against viruses like Covid. This was an extension of the examples of soap ( sodium oleate/stearate) and CPC. Incidentally, I have tremendous interest in oils and lipids, which was my first industry experience decades ago. I still maintain lot of interest. I would differ with your erstwhile Org. Professor on margarine. It is simply an everyday edible oil, presented in a different form, for a feel like butter. A few food grade ingredients are needed to make them. Based on that interest, I have commented quite a bit on the LNPs used for the vaccine encapsulation. We will continue to interact.
Nicotine’s chemical structure is a perfect fit as anti viral - if my premise is correct. Small, two rings, one a pyridine and the N-methyl pyrrolidine ring. The latter, in particular, can latch on to the cationic spike segments and render them useless. That is how, Nicotine can strip this virus. If I were a working drug (organic) chemist ( long retired, though), I would have added a Cetyl chain to the pyridine nitrogen, make it a powerful quarternary centre, which would protect the anionic surfaces of host cell walls from the approaching virus, a la, CPC (Cetyl Pyridinium Chloride), the common mouth wash ingredient that destroys this virus in seconds. That is some very simple chemistry at work. By the same mechanisms, Nicotine would also save cells from the lingering cationic lipid nano shells of m-RnA vaccines and even destroy them - eliminate one pathogenic source for long vax manifestations. People are benefiting from its use, but the experiences has not caught the attention of mainstream clinician.
Have you seen Dr. McMillan’s latest video on the protective effects of Nitrous Oxide ie production via gargling, humming, singing?
Gargling with CPC could very well be the 1,2 CPC NO antiviral punch needed to keep us out of the autoimmune phase, and may be a better option than dealing with nicotine’s toxic and other undesirable effects.
Could CPC also be the answer to Covid dysbiosis in the same way that nicotine’s anti microbial activity has been shown to help heal ulcerative colitis lesions?
Is using nicotine patches for long covid a good idea? For some people it has been. Using it for the prevention of Covid infection may or may not be a good idea. As for me, I won’t be using nicotine for the prevention of infection.
If anyone has info on the ability of nicotine to take care of bartonella in the gut, feel free to share as I’ve recently seen it implicated in IBD and biliary problems.
Is Bartonella a Cause of Primary Sclerosing Cholangitis? A Case Study
“it is postulated that at least some cases of PSC may be associated with Bartonella infection. The patient in this report was treated with oral vancomycin and, since then, has been in remission for both colitis and PSC. Since vancomycin is not systemically absorbed, the premise is that he suffered from Bartonella colitis and an autoimmune reaction to Bartonella causing PSC. This premise warrants further study.”
As an organic chemist, I would put my bets on electrostatic interactions ( cell walls, virus spike active sites) as to why CPC is so effective in deactivating this virus almost instantly. I don’t see any role for NO here, though by itself NO is powerful. With its similar structure, Nicotine could be as effective, for the same reasons. It is very much amenable for a synthetic conversion to a CPC analogue, in which case it is my guess that it can be devastatingly powerful for the virus. This conversion might possibly eliminate the concerns about nicotine. Any takers for this simple exploration ? Nicotine is used for weaning from smoking and as such all that is wrong about tobacco should not be ascribed to it. Tobacco has more than 3000 identified chemical constituents, including other alkaloids. Also, we are looking at only short/medium term therapy with these molecules, ideally in combination with others.
I personally saw a smoker I know get very sick with the delta variant, so I'm not convinced nicotine alone is the preventative answer to our anti-viral questions. Plus, I experimented with one of those nicotine patches (7mg) for my long-covid and it made me very sick. Maybe the lower dose nicotine gum would work, but 7mg is what has been used and said to work for some people. I've also seen what chewing tobacco does to some people the first time they chew it, not good. Nicotine poisoning is a real thing.
I think it's interesting that while I am an asthmatic, I have never had covid pneumonia.
Breathing in through the nose delivers NO directly into the lungs, where it helps fight coronavirus infection by blocking the replication of the coronavirus in the lungs.
https://www.sciencealert.com/there-s-a-proper-way-to-breathe-to-keep-your-lungs-healthy-and-it-could-help-against-the-coronavirus
I have read somewhere that Nicotine is not the main reason for the ills of Tobacco. It is a recreational drug. However, people could be sensitive to anything and in your example, nicotine was perhaps on the wrong side. I referred to it in my last line and I have specifically highlighted often in other places - single drugs are ok if the condition is prophylactic, like with Ivermectin in Covid, but in a fresh infection, therapy/treatment with repurposed drugs has to be a cocktail of drugs, including with Ivermectin. And it could be true of Nicotine also, in your example, used as the lone drug. For delta, it should have been part of a combination of Azithromycin, Montelukast, Levocetrizine etc, the most successful bunch that drove delta out of the park in India in the second half of 2021. The premise is simple. All these are part anti virals off label, this could include Nicotine also in my understanding. In the viral phase in the initial days, as the viral load rapidly grows, just a single drug may not be adequate to contain the build up, in most people. Only a combination of such molecules would pack enough anti viral fire power for the job. A simple clinical judgment miserably missed or ignored by the clinicians in the USA. This is true with Omicron also. Its mild presentations are deceptive. It is clear from the US experience that it too is capable off long Covid damages. So early combination drugs are needed to not let viral load build up beyond tipping levels. In my opinion, this could be true of the highly hailed Paxlovid also. As single drug, it did not have enough fire power and that is how its efficacy was about 30-40%. It needed the back up of one or two classical URT medicines. On Nicotine, the chemical magic could be to convert it in a simple step as a CPC analog. In my reckoning, such a molecule would have two anti viral points - the Cetyl quaternary Pyridine ring and and the existent N-methyl pyrrolidone point, which is a powerful tertiary amine location in the structure. It is still a new molecule, despite its similarity to two known drug molecules, and needs to go through its safety profile drill, after a quick in vitro evaluation.
Moro, it's always a joy to hear from you. While I do hold a minor in chemistry, I have to confess that organic chemistry was not my favorite year of learning, and the most profound thing I remember my O chem prof saying is that eating margarine is probably a bad idea. Biochemistry is something I enjoyed more than O chem, but clinical chemistry rocked my world because of the way the science of chemistry became the vehicle for diagnostic medicine to be used to heal people. Practical medicine needs science, but as you know applying that science is not as easy as the scientific studies often make things seem. Medicine also needs to catch up with science, I've heard its way behind in applying current scientific knowledge. Much wisdom is needed in order for each sick person to become an active participant in their treatment decisions. God bless you!
Thanks for your kind words. Appreciate. I have never worked in drug synthesis or developments and in the last few years, got attracted to reading about organic structures of drugs ( in my long retirement since). During those three plus years of Covid and following many reports on repurposed drugs, I looked at the structures of over 700 known drugs and formed a thought about some commonality in them ( not achieved by design certainly, but falling in place), about many of them being anti viral ( to viruses like the present one) and since have been propounding the view that 2000-3000 drug molecules we know today and use, some decades old, have multi indication potentials that must become the medicine pursuit for this century. In the process, helping half the population of the world who are now without access for cheap, effective, safe, readily available drugs - from cancer down to any everyday illness. I take part actively in conversations in quite a few good podcasts, including Dr. McMillan’s. I could be the only one in the hundreds and hundreds of active followers, talking from pure chemistry perspectives of drugs and treatments, even though I am not a medico myself. In recent times, I got Dr. Shankara Chetty interested in the possibility that ionic structured drugs could be powerful against viruses like Covid. This was an extension of the examples of soap ( sodium oleate/stearate) and CPC. Incidentally, I have tremendous interest in oils and lipids, which was my first industry experience decades ago. I still maintain lot of interest. I would differ with your erstwhile Org. Professor on margarine. It is simply an everyday edible oil, presented in a different form, for a feel like butter. A few food grade ingredients are needed to make them. Based on that interest, I have commented quite a bit on the LNPs used for the vaccine encapsulation. We will continue to interact.
Nicotine’s chemical structure is a perfect fit as anti viral - if my premise is correct. Small, two rings, one a pyridine and the N-methyl pyrrolidine ring. The latter, in particular, can latch on to the cationic spike segments and render them useless. That is how, Nicotine can strip this virus. If I were a working drug (organic) chemist ( long retired, though), I would have added a Cetyl chain to the pyridine nitrogen, make it a powerful quarternary centre, which would protect the anionic surfaces of host cell walls from the approaching virus, a la, CPC (Cetyl Pyridinium Chloride), the common mouth wash ingredient that destroys this virus in seconds. That is some very simple chemistry at work. By the same mechanisms, Nicotine would also save cells from the lingering cationic lipid nano shells of m-RnA vaccines and even destroy them - eliminate one pathogenic source for long vax manifestations. People are benefiting from its use, but the experiences has not caught the attention of mainstream clinician.
Have you seen Dr. McMillan’s latest video on the protective effects of Nitrous Oxide ie production via gargling, humming, singing?
Gargling with CPC could very well be the 1,2 CPC NO antiviral punch needed to keep us out of the autoimmune phase, and may be a better option than dealing with nicotine’s toxic and other undesirable effects.
Could CPC also be the answer to Covid dysbiosis in the same way that nicotine’s anti microbial activity has been shown to help heal ulcerative colitis lesions?
Is using nicotine patches for long covid a good idea? For some people it has been. Using it for the prevention of Covid infection may or may not be a good idea. As for me, I won’t be using nicotine for the prevention of infection.
If anyone has info on the ability of nicotine to take care of bartonella in the gut, feel free to share as I’ve recently seen it implicated in IBD and biliary problems.
Is Bartonella a Cause of Primary Sclerosing Cholangitis? A Case Study
“it is postulated that at least some cases of PSC may be associated with Bartonella infection. The patient in this report was treated with oral vancomycin and, since then, has been in remission for both colitis and PSC. Since vancomycin is not systemically absorbed, the premise is that he suffered from Bartonella colitis and an autoimmune reaction to Bartonella causing PSC. This premise warrants further study.”
Source-
https://www.mdpi.com/2624-5647/2/1/5
Clinical implications of nicotine as an antimicrobial agent and immune modulator
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320263/